Alain Karma
Distinguished Professor of College of Arts and Science
College of Arts and Science
Northeastern University

E-mail: Karma at neu.edu
Research Summary

My general research interest is to understand how complex patterns arise in physical and biological systems that are outside of thermodynamic equilibrium

Recent Publications
  • "Coupled Dynamics of Voltage and Calcium in Paced Cardiac Cells" Y. Shifreraw, D. Sato, A. Karma. To Be Published (2004)
  • "Two-phase microstructure selection in peritectic solidification: from island banding to coupled growth" T.S. Lo, S. Dobler, M. Plapp, A. Karma, and W. Kurz, Acta Materiala 51, 599-611 (2003).
  • "Model of intracellular calcium cycling in ventricular myocytes." Shiferaw Y, Watanabe MA, Garfinkel A, Weiss JN, Karma A. Biophys.J.85,3666-86(2003)
  • "Phase-Field Approach for Faceted Solidification" Jean-Marc Debierre, Alain Karma, Franck Celestini, Rahma Guerin Phys. Rev. E 68, 041604 (2003)
  • "Pattern Stability and Trijunction Motion in Eutectic Solidification" by S. Akamatsu, M.Plapp, G. Faivre, A. Karma Materials Science 2002, 4, 535-539
  • "Instability and Spatiotemporal Dynamics of Alternans in Paced Cardiac Tissue" by B. Echebarria and A. Karma Phys. Rev. Lett. 88, 208101 (2002)
Students
Graduate Students:
  • Przemek Koczynski (PhD, 1998)
  • Youngy Lee (PhD, 1998)
  • T.S. Lo
  • Flavio Fenton
Postdocs:
  • Mathis Plapp
  • Youngy Lee
Other Info.
A Family Photo:
Prof. Karma and son
[Professor Karma and his son]
Funding:
Department of Energy, NASA and American Heart Association

Solidification Patterns:

One important class of nonequilibrium patterns are those produced naturally and unavoidably by the solidification process, such as the snow-flakes familiar to Bostonians and the dendrites familiar to casting and welding engineers. These structures determine the physical properties (e.g. the tensile strength) and quality of many man made objects. Thus, understanding how they form is practically relevant.

Modeling solidification microstructures quantitatively is rendered extremely difficult by tracking the highly nonlinear evolution of the solid-liquid interface and, moreover, by the fact that the basic lengthscales that control this evolution differ by several orders of magnitude. Surface tension acts on a nanometer scale whereas heat and mass transport by diffusion takes place on a scale of a millimeter. Convective transport can act on even larger scales. The current research in my group focuses on further developing a phase-field approach, inspired from continuum models of phase transitions, in order to cope with both of these difficulties. Using a reformulated asymptotic analysis of the phase-field model and a Monte Carlo treatment of the long range diffusion field, we are just reaching the point of making benchmark predictions of dendritic growth that can be compared directly to low undercooling experiments in three dimensions.

3d Dendritic 2
Movie of 3D dendritic growth in an undercooled melt.
(1.5 MB in fli format)
3D Dendritic 3
(2.0 MB in fli format)

3D Scroll Filament
Movie of 3D scroll filament breakup (1.8 MB in fli format)

Cardiac Dynamics:
"Spiral waves" are characteristic structures of excitable media that have been observed in systems as different as catalytic surface oxidation, the Belousov-Zhabotinsky chemical reaction, aggregating colonies of slime mold, and heart tissue where they are suspected to play an essential role in cardiac arrhythmia and fibrillation. Our current research focuses on studying the generic behavior of two-dimensional spiral waves and three-dimensional scroll waves in isotropic/homogeneous excitable media, and on understanding how this behavior is altered by the architecture of the anisotropic/non-homogeneous heart muscle. The long term partical aim of this research, in terms of human helath, is to render modeling sufficiently realistic and accurate to guide the search for successful antifibrillatory drugs, implented low voltage defibrillators, and improved surgical procedures.
Sprial waves
Spiral waves
Preprints:
Recent preprints listed below are posted on the Los Alamos condmat preprint server can can be downloaded electroncially from the web in various formats at http://xxx.lanl.gov/archive/cond-mat

Title: Eutectic Colony Formation: A Stability Analysis
Authors: Mathis Plapp and Alain Karma cond-mat/9812376 (23 Dec 1998)

Title: Phase-Field Model of Dendritic Sidebranching with Thermal Noise
Authors: Alain Karma and Wouter-Jan Rappel cond-mat/9902017 (1 Feb 1999)

Title: Theory of spiral wave dynamics in weakly excitable media: asymptotic reduction to a kinematic model and applications
Authors: Vincent Hakim and Alain Karma cond-mat/9903262 (Wed 17 Mar 1999)

How to play FLI/FLC movies:
You will need one of the following players:
For workstations under X-windows: Xanim
For PC's under DOS/Windows3.1: Autodesk Animation Player
For machines under Win95/NT: PowerFLic
For Mac's : MacAnim Viewer 1.1 or Fli-Viewer
Once you click on the FLI-movie your browser will save the file on your directory and you can see it using one of the players. If you want to see the movie on the fly you have to tell you browser to recognize the .fli and .flc as extensions for movies so it can use the appropriate FLI/FLC player. For example on a Unix machine you need to add the following on your .mailcap file in your home directory:

# This maps all types of video *other than MPEG* to the viewer
# 'xanim'.
video/*; xanim %s