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Alain Karma
Distinguished Professor of College of Arts and Science
College of Arts and Science
Northeastern University
E-mail: Karma at neu.edu
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Research Summary
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My general research interest is to understand how complex patterns arise in physical and biological systems that are outside of thermodynamic equilibrium
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Recent Publications
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- "Coupled Dynamics of Voltage and Calcium in Paced
Cardiac Cells" Y. Shifreraw, D. Sato, A. Karma.
To Be Published (2004)
- "Two-phase microstructure selection in peritectic
solidification: from island banding to coupled growth"
T.S. Lo, S. Dobler, M. Plapp, A. Karma, and W. Kurz,
Acta Materiala 51, 599-611 (2003).
- "Model of intracellular calcium cycling in ventricular
myocytes." Shiferaw Y, Watanabe MA, Garfinkel A, Weiss
JN, Karma A. Biophys.J.85,3666-86(2003)
- "Phase-Field Approach for Faceted Solidification"
Jean-Marc Debierre, Alain Karma, Franck Celestini, Rahma
Guerin Phys. Rev. E 68, 041604 (2003)
- "Pattern Stability and Trijunction Motion in Eutectic
Solidification" by S. Akamatsu, M.Plapp, G. Faivre,
A. Karma Materials Science 2002, 4, 535-539
- "Instability and Spatiotemporal Dynamics of Alternans
in Paced Cardiac Tissue" by B. Echebarria and A. Karma
Phys. Rev. Lett. 88, 208101 (2002)
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Students
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Graduate Students:
- Przemek Koczynski (PhD, 1998)
- Youngy Lee (PhD, 1998)
- T.S. Lo
- Flavio Fenton
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Postdocs:
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Other Info.
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A Family Photo:
[Professor Karma and his son]
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Funding:
Department of Energy,
NASA and
American Heart Association
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Solidification Patterns:
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One important class of nonequilibrium patterns are those
produced naturally and unavoidably by the solidification process, such
as the snow-flakes familiar to Bostonians and the dendrites familiar
to casting and welding engineers. These structures determine the physical
properties (e.g. the tensile strength) and quality of many man made
objects. Thus, understanding how they form is practically relevant.
Modeling solidification microstructures quantitatively is rendered extremely
difficult by tracking the highly nonlinear evolution of the solid-liquid
interface and, moreover, by the fact that the basic lengthscales that
control this evolution differ by several orders of magnitude. Surface
tension acts on a nanometer scale whereas heat and mass transport by
diffusion takes place on a scale of a millimeter. Convective transport
can act on even larger scales. The current research in my group focuses
on further developing a phase-field approach, inspired from continuum
models of phase transitions, in order to cope with both of these difficulties.
Using a reformulated asymptotic analysis of the phase-field model and
a Monte Carlo treatment of the long range diffusion field, we are just
reaching the point of making benchmark predictions of dendritic growth
that can be compared directly to low undercooling experiments in three
dimensions.
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Movie of 3D dendritic growth in an undercooled melt.
(1.5 MB in fli format)
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(2.0 MB in fli format)
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Movie of 3D scroll filament breakup (1.8 MB in fli format)
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Cardiac
Dynamics:
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"Spiral waves" are characteristic structures
of excitable media that have been observed in systems as different as
catalytic surface oxidation, the Belousov-Zhabotinsky chemical reaction,
aggregating colonies of slime mold, and heart tissue where they are suspected
to play an essential role in cardiac arrhythmia and fibrillation. Our
current research focuses on studying the generic behavior of two-dimensional
spiral waves and three-dimensional scroll waves in isotropic/homogeneous
excitable media, and on understanding how this behavior is altered by
the architecture of the anisotropic/non-homogeneous heart muscle. The
long term partical aim of this research, in terms of human helath, is
to render modeling sufficiently realistic and accurate to guide the search
for successful antifibrillatory drugs, implented low voltage defibrillators,
and improved surgical procedures.
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Spiral waves
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Preprints:
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Recent preprints listed below are posted on the Los Alamos
condmat preprint server can can be downloaded electroncially from the web
in various formats at http://xxx.lanl.gov/archive/cond-mat
Title: Eutectic Colony Formation: A Stability
Analysis
Authors: Mathis Plapp and Alain Karma cond-mat/9812376 (23 Dec
1998)
Title: Phase-Field Model of Dendritic Sidebranching
with Thermal Noise
Authors: Alain Karma and Wouter-Jan Rappel cond-mat/9902017 (1
Feb 1999)
Title: Theory of spiral wave dynamics in weakly
excitable media: asymptotic reduction to a kinematic model and applications
Authors: Vincent Hakim and Alain Karma cond-mat/9903262 (Wed 17
Mar 1999)
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