Paul Champion
Professor of Physics
Department of Physics
Northeastern University

E-mail: champ at neu.edu
Research Summary

Fields of Specialization and Interests:

  • Chemical Physics, Molecular Biophysics
  • Light-matter interaction and electron-nuclear coupling (resonant light scattering, absorption, fluorescence, electron transport, protein fluctuations and kinetics).
  • Application of resonance Raman and femtosecond coherence spectroscopy, Mössbauer spectroscopy, electron paramagnetic resonance, magnetic susceptibility, far infrared magnetic resonance, transient absorption and optical holeburning techniques to biological materials.

Recent Publications
  • "Resonance Raman investigations of Escherichia coli-expressed Pseudomonas putida cytochrome P450 and P420" Wells AV, Li P, Champion PM, Martinis SA, Sligar SG. Biochemistry 42, 6149 (2003)
  • "Long-Range Reactive Dynamics in Myoglobin" J. Timothy Sage, Stephen A Durbin, Wolfgang Sturhahn, David C. Wharton. Paul A Champion, Philip Hession, John Sutter and E. Ercan Alp. Physics Review Letters, Vol. 86, Num. 21
  • "Investigations of Anharmonic Low-Frequency Oscillations in Heme Proteins" Florin Rosca, Anand T. N. Kumar, Dan lonascu, Xiong Ye, Andrey A. Demidov, Theodore Sjodin, David Wharton, Douglas Barrick, Stephen G. Sligar, Takashi Yonetani, and Paul M. Champion. The Journal of Physical Chemistry A, vol. 106, No. 14, 2002
  • "Measurements of the Photodissociation Quantum Yields of MbNO and MbO2 and the Vibrational Relaxation of the Six-Coordinate Heme Species" Xiong Ye, Andrey Demidov, and Paul M. Champion. Journal of the American Chemical Society, vol. 124, NO. 20, 2002
  • "Low Frequency Modes in Heme Proteins" Florin Rosca, Anand T. N. Kumar, Dan lonascu, Xiong Ye, Andrey A. Demidov, and Paul M. Champion. The Chemical Society of Japan, Bull. Chem. Soc. Jpn., 75, 1093-1101 (2002)
Recent Talks/Conferences
  • University of Michigan, November 2000, "Femtosecond Coherence Spectroscopy of Biomolecular Reaction Dynamics." Biophysics Colloquium.
  • Los Alamos National Laboratory, November 2000, "Femtosecond Coherence Spectroscopy of Biomolecular Reaction Dynamics." International Workshop on Myoglobin.
  • International Conference on Chemistry in the Pacific Rim, Pacifichem 2000, Honolulu Hawaii, December 2000, "Femtosecond Coherence Spectroscopy of Biomolecules", Invited Symposium lecture.
  • Tenth International Conference on Time-Resolved Vibrational Spectroscopy, Okazaki, Japan, May 2001, "Detection of Low Frequency Modes in Heme Proteins Using Femotsecond Spectroscopy", Invited Talk.
  • Fourth International Discussion Meeting on Relaxations in Complex Systems, Crete, Greece, June 2001, "Detection of Low Frequency Modes in Heme Proteins Using Femotsecond Spectroscopy", Invited Talk.
Students
  • Kevin Schomaker, September 1987
    Thesis: "Absorption, Resonant Rayleigh and Resonant Raman Properties of Cytochrome C"
  • Opa Bangcharoenpourpang, June 1988
    Thesis: "Resonance Raman Studies of Myoglobin, Cytochromes P450 and Chloroperoxidose"
  • Dimitios Morikis, June 1990
    Thesis: "Resonance Raman Investigations of Heme Proteins in the Liquid, Frozen and Crystalline Phase: A Study of the Heme Pocket of Myoglobin"
  • Vukica Srajer, May 1991
    Thesis: "Optical Aborption, Kinetics and Kinetic Hole-burning as a Probe of Myoblobin Structure and Dynamics"
  • Pusheng Li, June 1994
    Thesis: "Raman Scattering Studies of Heme Proteins"
  • Yuangang Gu, July 1994
    Thesis: "Photoreduction, Optical Lineshape and Raman Studies of Heme Proteins"
Other Info.
Honors:
  • Phi Kappa Phi
  • NSF/CNRS Exchange Fellow
  • L.P. Kinnicutt Assistant Professor of Chemistry
  • NIH Research Career Development Award
  • Visiting Fellow, Institute of Molecular Science (Okazaki, Japan)
  • Fellow, American Physical Society
  • Divisional Editor: Physical Review Letters (1994-2000) Biological Physics
  • Editorial Board: Journal of Raman Spectroscopy, Biospectroscopy
  • International Steering Committee: International Conference on Raman Spectroscopy
  • International Steering Committee: Time Resolved Vibrational Spectroscopy
  • Member of NIH Study Section on Molecular and Cellular Biophysics 1999-2003
  • Japanese Society for the Promotion of Science (Fellowship)
Professional Experience:
  • 1966 - 1968 Undergraduate Research Assistant, Atomic Energy Commission (Ames Lab)
  • 1968 - 1972 Full-time Teaching Assistant, University of Illinois
  • 1972 - 1975 Research Assistant, University of Illinois
  • 1975 - 1976 Research Associate, Laboratory of Atomic and Solid State Physics, Cornell University
  • 1976 - 1979 Research Associate, Chemistry Department and Materials Science Center Laser Facility, Cornell University
  • 1979 - 1980 NSF/CNRS Exchange Fellow, Institut de Biologie Physico-Chimique, Paris, France
  • 1979 - 1981 Senior Research Associate, Laboratory of Atomic and Solid State Physics, Cornell University
  • 1981 - 1984 Assistant Professor of Chemistry, Worcester Polytechnic Institute
  • 1984 - 1990 Associate Professor of Physics, Northeastern University
  • 1990 - 1992 Professor of Physics and Executive Officer, Northeastern University
  • 1993 - Professor of Physics and Chair, Northeastern University
Major Research Funding:
  • Principal Investigator of research grant "Near Ultraviolet Raman Studies of Cytochrome P-450" funded by National Institutes of Health, $210,821 (1979-1983). Continuation award, $430,512 (1983-88). Continuation award, $670,000 (1988-1993). Continuation award, $1,060,000 (1993-1998). Continuation award $1,414,143 (1998-2003).

  • Principal Investigator of research grant "Resonance Raman Studies of Electron-Nuclear Coupling, Time Resolved Dynamics, and Magnetic Perturbations of Biomolecules" funded by National Science Foundation, $195,000 (1985-1988). Continuation award, $231,000 (1988-1991). Continuation award, $294,000 (1991-1994). Continuation award $601,000 (1994-1999). Continuation award $400,000 (1999-2002).
  • Co-Principal Investigator of research grant "Nuclear Resonance Spectroscopy of Biomolecules" funded by National Science Foundation, $224,431 (2000-2003).
Professional Societies:
  • American Physical Society ~ Executive Committee (1990-1993) Biological Physics
  • American Chemical Society
  • American Association for the Advancement of Science
  • Biophysical Society
  • Society for Applied Spectroscopy


Education:

B.S. 1968 Iowa State University
M.S. 1972 University of Illinois
Ph.D. 1975 University of Illinois